This study assessed the effects of three methods of drying (oven, sun and smoke) on the biochemical composition of two fish species, Chrysicthys nigrodigitatus and Micropogonias undunlatus. The fish samples were analyzed using Potato Dextrose Agar and Nutrient Agar for fungi and bacteria respectively in the fish samples, the genera of isolates identified includes: Aspergillus, Mucor, Proteus, Bacillus, Staphylococcus, and Escharichia. Fresh samples of C. nigrodigitatus had higher (52.00±16.00a) bacteria and fungi (19.00±6.56ab) content than M. undulatus bacteria (48.45±40.78a) and fungi (16.33±2.08a) content. The mean bacteria count in oven dried M. undulatus (82.67±36.30a) ranked highest while smoke-dried M. undulatus ranked lowest. The mean fungi count in oven dried M. undulatus (19.67±2.08a) ranked highest while sun dried M. undulatus (15.67±2.13a) ranked lowest, however, no significant difference (p>0.05) was observed in the mean bacteria and fungi count between smoking methods. The mean bacteria and fungi count of smoke-dried and sun dried C. nigrodigitatus ranked higher than values observed in other processing methods; however, no significant difference (p>0.05) was observed in the bacteria and fungi count between smoking methods. The proximate composition and minerals content of the sample were determined using standard methods. Sun dried M. undulatus recorded the highest (19.70%) moisture content while the least moisture content 12.67% were obtained in smoke dried M. undulatus. Highest protein content (69.70%) was found in smoke dried M. undulatus, the least protein content (61.17%) was recorded in Sun dried. The highest and least fat value of 10.37% and 5.47% were recorded for smoke-dried and Oven dried C. nigrodigitatus. respectively. M. undulatus oven dried (8.17%) have the highest ash content of all the fish evaluated while the least (4.76%) was found in smoke dried C. nigrodigitatus for proximate composition. The moisture, protein, fat, ash, crude fibre and carbohydrate contents in both samples showed significant difference (P<0.05) between the various drying methods. The highest value of the major elements were obtained in this decreasing order K>Na>Mg>Ca in M. undulatus and C. nigrodigitatus (oven-dried) in both K and Na, M. undulatus (smoked dried) and C. nigrodigitatus (smoke dried). The highest value of major element K and Na M. undulatus (2100mg, 1616mg), C. nigrodigitatus (1346mg, 1036mg), Mg M. undulatus (883mg), Ca C. nigrodigitatus (512mg) were obtained respectively, Iron had the highest value of all the trace elements determined while lead had the least value. The mineral analyzed of C. nigrodigitatus and M. undulatus revealed the Significant difference (p<0.05) in the composition of this minerals.